Therapies for immune diseases continue to attract Pharma’s attention (and money). This time, two of 25 leading Big Pharma worldwide, AbbVie and Boehringer Ingelheim, have partnered to develop 2 different immunological candidates.
One of the candidates is BI 655064, an antagonistic anti-CD40 antibody in phase I development. Tackling the CD40-CD40L pathway (involved in modulating immune response), it could potentially be used to treat a range of immune diseases like lupus nephritis, Crohn’s disease and ulcerative colitis.
But the forefront candidate is BI 655066, which is already in phase III trials. The drug is an anti-IL-23 antibody, which aims to block Interleukin-23 (signalling protein) involved in skin inflammation.