Cellectis’ Miraculous Saving of a Baby Girl. What’s the impact on the CAR-T field?

06/11/2015 - 2 minutes

About 30%. That’s how Cellectis‘ NASDAQ stock price has jumped between the 4th and the 5th of November. But why? Basically, because of the first human success of their allogeneic CAR-T therapy!

Picture1The Great Ormond Street Hospital (UK) treated a young patient with refractory relapsed Acute Lymphoblastic Leukemia (ALL) with Cellectis’ allogeneic UCART19 product candidate in June. To put this plainly, the CAR-T therapy was her last chance…and miraculously, after only two months she seems to be cured!

This is a huge deal for many patients around the world who could benefit from such therapies in the future. Competitors approaches include autologous CAR-T therapy which worth several hundreds thousand dollars per treatment, and therefore limit the number of patients which can access those therapies.

Cellectis’ allogeneic CAR-T therapy can be manufactured as one batch for several patient (allogeneic means that we extract T cells from a health patient as opposed to autologous which is from the patient). That will therefore drastically reduce the cost of the therapy.

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