Celyad failed to get significant results in its Phase III trial in cardiac disease. However, this cell therapy could still have a positive effect in a part of the patients. True potential or public relations patch?
Cardiovascular diseases are the leading cause of death worldwide. Biotech solutions in the field range from gene therapy (with uniQure and BMS) to enzyme stabilization (a Swedish strategy that closed a €100M deal) and even neurostimulation.
Cell therapy also had a place in cardiovascular diseases with Celyad’s C-Cure. Celyad (Belgium) has a platform to derive cardiopoietic cells from a patient’s bone marrow. After this procedure, the cells were reinjected into the patient’s heart and differentiate into normal heart cells.
Now, topline results of C-Cure’s Phase III trial (CHART-1) were just published, but they don’t look great. The therapy didn’t meet the trial’s primary endpoint: a statistically significant improvement of outcome for patients with chronic advanced ischemic heart failure.