This license agreement opens new markets to Celyad and its NKR-2 T-cell cancer immunotherapy. In addition to a deal worth up to €282M, Celyad will also receive double digit royalties based on net sales of the licensed product in Japan-based ONO’s territories.
Celyad’s Natural Killer Receptor (NKR) based T-Cell platform targets a wide range of solid and hematological tumors, and is currently in Phase I trials for acute myeloid leukemia and multiple myeloma patients.
Unlike traditional CAR-T cell therapy, which target only one tumor antigen, NK cell receptors enable a single receptor to recognise multiple tumor antigens. The trial is designed to assess the safety and feasibility of NKR-2, with secondary endpoints including clinical activity.
Additional benefits of this approach include the fact that the NKR-2 program does not employ patient pre-conditioning of the immune system,