Unique Natural Killer T-Cell Therapy secures €282M in Japan Deal

12/07/2016 - 3 minutes

Belgian Celyad granted an exclusive license to Osaka based ONO Pharmaceutical for the development and commercialisation of Celyad’s unique allogeneic cell therapy in Japan, Korea and Taiwan.

Celyad biotech cancer ono car-t nkThis license agreement opens new markets to Celyad and its NKR-2 T-cell cancer immunotherapy. In addition to a deal worth up to €282M, Celyad will also receive double digit royalties based on net sales of the licensed product in Japan-based ONO’s territories.

Celyad’s Natural Killer Receptor (NKR) based T-Cell platform targets a wide range of solid and hematological tumors, and is currently in Phase I trials for acute myeloid leukemia and multiple myeloma patients.

Unlike traditional CAR-T cell therapy, which target only one tumor antigen, NK cell receptors enable a single receptor to recognise multiple tumor antigens. The trial is designed to assess the safety and feasibility of NKR-2, with secondary endpoints including clinical activity.

Additional benefits of this approach include the fact that the NKR-2 program does not employ patient pre-conditioning of the immune system,

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