A New feat in Nanomedicine: The Cubosome drug delivery system has now been 3D-mappped and studied internally by Scientists from the Swiss Federal Institute of Technology (EPFL) and University of Coimbra (Portugal) at the Nestlé Research Center in Lausanne (Switzerland).
What are Cubosomes? These small nanostructures are ‘crystalline liquid phases’ engineered in bulk to hold drugs and deliver them to target tissue intravenously. Although also lipid based, they differ from other drug-carrier systems such as liposomes due to their cubic shape. Published in Nature Communications , the research team at EPFL used cryo-electro tomography (CET) techniques to image and 3-dimensionally map the internal structure of these cubosomes, to better understand their bio-compatability.
This technique meant embedding the cubosome structures into a glass-like sheet of ice, which is then lowered to -170°C for imaging of the structures at the Centre for Electron Microscopy (CIME) at EPFL in Lausanne. Such methods of CET imaging help give better definition to biological strucutres,