InflaRx has treated the first patient in a new Phase II trial, which is studying the potential of its anti-complement antibody in avoiding immunological complications after complex cardiac surgery – a big unmet need. It is competing with world most expensive drug Soliris from Alexion (US).
Based in Jena (Germany), InflaRx specializes in developing new drugs to control inflammation. In order to do this, it targets the complement system – small proteins or peptides that stimulate the action of antibodies and immune cells.
Its lead candidate is IFX-1, a first-in class monoclonal antibody that binds to a particularly sought-after target of the complement system – C5a. This protein fragment is a key amplifier of inflammatory response.
InflaRx is applying its IFX-1 in a particular area of high unmet needs – complex cardiac surgery. In this kind of open-heart procedures, the patient is connected to a heart-lung-machine and the blood contacts with artificial surfaces – which can cause systemic, life-threatening inflammation.
The Phase II trial for this application has now been initiated,