High-Throughput screening of drug candidates made easier by FRETinFLOW

14/09/2015 - 4 minutes

A multidisciplinary team from France has come up with a robust approach to detect molecular interactions in a reliable way using flow cytometry. This technology could lead to the discovery of new drugs via High-Throughput screening.

Flow cytometry is a laser-based, biophysical technology employed by scientists all over the world to count and sort cells. It does this by suspending the cells in a stream of fluid and then passing them through a piece of electronic detection apparatus. Furthermore, Försters resonance energy transfer (FRET), is a non-invasive technology that permits the study of protein interactions with a resolution of 1-10nm.

Various methodological and conceptual advances are required to chart comprehensive protein interaction maps and understand the complexity of networks. Similarly, much also needs to be done in order to characterize protein modulators. In this regard, the FRET approach represents an alternative to study these interactions in vivo. In addition, when the rapidity and multiparametric properties of flow cytometry are combined with the precision and resolution capabilities of FRET,

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