Viral Immunotherapy Trial Failure Causes French Biotech Stocks to Drop 43%

28/01/2016 - 3 minutes

Genticel (France) is a clinical biotech developing a cervical cancer immunotherapy against the Human papillomavirus. However, their 24-month phase II trial has failed to meet primary endpoint at its halfway point, and their stocks dropped 43% overnight. 

genticel_hpv_biotechAround 70% of cervical cancer cases are caused by 2 types of Human papillomavirus (HPV): 16 and 18. And among the 300 million women around the world currently infected with HPV, there is a strong relationship to the development of Cervical cancer (of which 275,000 women die each year).

Genticel aims to the address the risk of Cervical cancer at an early stage with GTL001, its first immunotherapeutic candidate to act against the infection. Branded ProCervix, GTL001 is a bivalent HPV vaccine. However, it is only designed for treatment of HPV infection before the appearance of high-grade cervical lesions or cancer.

The phase II trial with GTL001 (being used with imiquimod) has enrolled 239 patients across 7 Western European countries and is only at its midway point.

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