MorphoSys and Emergent BioSolutions Initiate Phase I

09/03/2015 - 3 minutes

MorphoSys AG and Emergent BioSolutions will initiate a Phase I clinical study to evaluate the safety, tolerability, and clinical activity of MOR209/ES414 in patients with metastatic castration-resistant prostate cancer (mCRPC).

A few months ago, we talked about the beginning of the collaboration between MorphoSys and Emergent BioSolutions. Now, the fruit of their combined work, an immunotherapeutic protein iMOR209/ES414 is going to initiate phase I clinical study to evaluate the novel oncology immunotherapeutic MOR209/ES414 for prostate cancer. The protein was developed by Emergent using its proprietary ADAPTIRTM (modular protein technology) platform. Preclinical in vitro and in vivo studies have shown MOR209/ES414 redirects T-cell cytotoxicity towards cells expressing prostate specific membrane antigen (PSMA), an antigen commonly found in prostate cancer cells.

Arndt Schottelius, Chief Development Officer of MorphoSys, said: “MOR209/ES414 has the potential to address a clear unmet medical need in prostate cancer. We are thus delighted to see this compound moving into the clinic as expected in early 2015. This is the fourth clinical candidate in our growing proprietary portfolio of compounds and increases the total number of clinical programs in our pipeline to 23.

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