Announced at the American Society of Hematology (ASH) Annual Meeting this weekend in Orlando (US), the phase I/IIa drug for blood cancer from MorphoSys has shown good tolerability for this Munich based Biotech. Indeed, the results are so encouraging that the candidate has best-in-class tolerability profile for the 52 patients with relapsed/refractory Multiple myeloma enrolled on the trial.
MOR202 is a fully human monoclonal HuCAL antibody targeting CD38, a highly expressed and validated target in multiple myeloma. CD38 is a promising target for the treatment of this type of cancer and potentially for hematological malignancies too. As Arndt Schottelius from MorphoSys explained:
The clinical study will continue as planned, focusing on combination cohorts, as we see the highest potential for MOR202 in combination therapy“
An effective antibody against this target could not only change future treatment regimens in multiple myeloma,