Alzheimer’s disease has a new case every three seconds, totaling up to 9.9 million new cases of dementia every year.
To combat this, AC Immune will offer Nestlé its expertise in biology and pathology of the Tau protein (abundantly found within the central nervous system) with its laboratory capacity to support the research program. The NIHS will provide its technology platform for antibody detection, in order to identify and validate an in vitro diagnostic test for the highly sensitive detection of the tau protein in cerebrospinal fluid (CSF) and blood plasma.
In Alzheimer’s, hyperphosphorylation of normal Tau protein within neuronal cells disrupts the proteins function, leading to the creation of microtubule ‘tangles’. These tau-protein tangles slow neuronal transmission and drives the degenerative tissue damage seen in this disease (for a more in depth visual explanation of Tau in Alzheimer’s,