Oxfordshire based PsiOxus will team up with the Immuno-Oncology Giant, Bristol-Myers Squibb, to test the combinatorial effect of their blockbuster drug with an Oncolytic viral therapy in late-stage cancer patients.
Together they will evaluate the safety, tolerability, and preliminary efficacy of PsiOxus’ Enadenotucirev, a systemically administered oncolytic adenovirus therapeutic, in combination with Bristol-Myers Squibb’s Opdivo blockbuster (nivolumab), which is projected to make €6.3Bn in annual sales by 2020.
Enadenotucirev is designed to have immune stimulating effects. On the other hand, Opdivo is designed to alleviate immune suppression as a PD-1 immune checkpoint inhibitor for metastatic non-small cell lung cancer (NSCLC), for renal cell carcinoma (RCC), classical Hodgkin’s Lymphoma and unresectable or metastatic melanoma as a mono- or combination therapy.
Solid tumors are a significant challenge in Immuno-Oncology, given that the internalised cancer cells in the mass are not easily exposed to therapies to attack. This means multiple rounds of treatments are needed, which can lose efficacy over time –