RNA therapy starts first-of-a-kind trial to treat Liver Cancer

02/06/2016 - 2 minutes

MiNA Therapeutics is launching the first saRNA human trial of its kind – OUTREACH for patients with severe liver cancer.

mina_therapeutics_biotech_rna_liver_cancer_trialMiNA Therapeutics is a London based RNA specialist, developing RNA activation therapeutics that restore normal function to patients’ cells with an initial focus on severe liver cancer. 

The study is the first-in-human trial of a small activating RNA (saRNA) and is designed to assess the safety and tolerability of their candidate MTL-CEBPA.

MTL-CEBPA consists of a double stranded RNA molecule, formulated into a ‘Smarticles‘ (liposomal nanoparticles) which are designed to activate the CEBPA gene.

The CEBPA gene encodes for the CCAAT/enhancer binding protein alpha (C/EBP-a), a transcription factor that acts as a master regulator of cell lineage determination and differentiation in several tissues including liver, myeloid cells and adipose tissue.

miNA_liver_cancer_phase_I_biotech

Related Content

C/EBP-a plays an important role in normal liver function and the benefits of increasing its expression have been demonstrated in multiple pre-clinical models of disease.

This content is available exclusively to our paying members.

Our members receive the following benefits:

  • Unlock premium articles
  • Download our industry reports
  • Remove all banner ads
  • Access 1,500+ archived posts
  • Support our independent media
Already a member? Sign in
ADVERTISEMENT
Do you want to remove this advert? Become a member!
ADVERTISEMENT
Do you want to remove this advert? Become a member!

You might also be interested in the following:


Support Us

Become a Member