CRISPR Can Help The Switch To Sustainable Cosmetics

Jon Kratochvil ers genomics crispr 1

The cosmetics industry is looking for greener ingredients as consumers demand more sustainable products. According to Jon Kratochvil at ERS Genomics, which licenses out patents belonging to the gene editing pioneers Emmanuelle Charpentier and Jennifer Doudna, CRISPR-Cas9 could one day meet the demand for alternatives.

The global cosmetics industry is worth more than €480B ($500B), but relies on ingredients that are unsustainable and cause harm to plant and animal life. Some products are sourced from animals directly and many others cause harm indirectly by persisting and accumulating in the environment.

Growing awareness of this problem among consumers has fueled a demand for something different, with green cosmetics emerging as a strong new trend in the beauty industry. In Europe, the natural cosmetics market generated almost €2B in revenue in 2020, expected to rise to almost €3B by 2025. Globally, this market is predicted to be worth €46B ($48B) by 2025

Consumers are increasingly seeking products with plant-derived, ‘natural’ ingredients and turning away from those containing animal-derived or environmentally damaging components. So what’s fueling the hype?

Many cosmetic ingredients are unsustainable

Many ingredients commonplace on the labels of cosmetics are animal-derived and environmentally unsustainable. These include squalene and its derivative squalane, naturally-occurring fatty substances used in a host of products, from moisturizers and sunscreen to lipstick and more. 

However, much of the squalene in the cosmetic industry comes from sharks. Shark liver oil is a particularly rich source of squalene and global demand is in the region of 2,200 tons, 90% of which is destined for cosmetics. With 3,000 sharks needed to produce just 1 tonne of squalane, this is a simply unsustainable demand for populations already threatened with overexploitation. 

Although plant-based alternatives are available, including squalane derived from olives, rice, and sugar cane, plant-based sources produce significantly lower yields of squalane. This makes it harder to extract and therefore more expensive than shark-derived squalane, leaving many manufacturers little choice if they are to compete on price.

Plant-based ingredients are not a perfect solution for the environment, either. Growing and harvesting any plant has an environmental impact, particularly when it takes place in already vulnerable ecosystems and without restriction. Palm oil is a well-established example of this problem, with the devastating impacts of its harvesting including tropical deforestation and biodiversity loss. 

Consumers are becoming increasingly aware of the environmental impacts of palm oil and many strive to avoid it, but what about lesser-known plant-based ingredients making their way into the cosmetics cabinet? 

Moroccan argan oil has become a highly prized, fashionable ingredient in products for hair, skin, and nails, quickly propelling it to become the most expensive edible oil in the world. Yet this popularity has also come at great environmental cost to the regions where it is produced.

Bakuchiol is another trendy but potentially unsustainable ingredient. Derived from the Babchi plant native to India, bakuchiol is becoming increasingly popular in skincare products as it offers similar benefits to retinol but without the side effects. As a result, natural populations of the Babchi plant, which is already endangered, are increasingly at risk from indiscriminate and illegal harvesting. 

Whatever the origin, intensive processing is generally required to extract precious biomolecules from their source, which creates its own environmental impact and comes at a cost to the consumer. 

In a world where consumers are increasingly savvy about the sources of ingredients, the cosmetics industry clearly cannot continue to rely on unsustainable and environmentally harmful ingredients, even though they may be labeled as ‘natural’. So, what’s the alternative?

CRISPR-ing the cosmetics cabinet

Instead of relying on nature to produce the compounds and quantities required by the global beauty industry, gene-editing technology can reduce demand for precious and limited natural resources.

Microbes, including yeast, algae, fungi, and bacteria, are capable of producing a range of biomolecules that form the basis of many cosmetics ingredients. These include terpenoids – the precursors of squalene – as well as fatty acids, enzymes, peptides, vitamins, and pigments.

Genetic engineering provides the opportunity to fine-tune these existing metabolic pathways, or create entirely novel ones, to make biomolecule production more efficient. 

CRISPR-Cas9, a highly precise gene-editing technology, sidesteps the shortcomings of its forerunners by being able to repress or activate existing genes within an organism, or insert new ones, at highly precise locations using a simple design scheme. In this way, CRISPR-Cas9 can be used to engineer microbes to make nature-based cosmetic ingredients using standard biotechnology facilities.

The possibilities CRISPR offers the cosmetics industry are endless. For example, Swiss biotech Evolva is using CRISPR to develop nature-based flavors, fragrances, and other cosmetics ingredients.

Compounds already being produced by the company include nootkatone, a citrus compound found in grapefruit peel. Nootkatone is used in perfumes to create a fresh, clean scent, but is notoriously expensive due to the small quantities found in nature and the costs of extraction. Evolva’s version though, produced by fermentation with genetically engineered yeast, is sustainable, cost-effective, and of consistent quality.

Elsewhere, CRISPR-Cas9 is already being used to modify terpenoid synthesis pathways in microbes to lead to overproduction of squalene, creating a sustainable, scalable source that does not involve harm to animals or inefficient crop processing.

Several biotech companies have also set to work using the latest advances in CRISPR gene editing to successfully generate a microbial palm oil alternative using various strains of yeast.

CRISPR is set to revolutionize how the cosmetic industry sources its ingredients. Although synthetic alternatives currently remain more expensive than their naturally derived counterparts, it is likely that consumer pressure – combined with legislative changes and application of innovative technologies like CRISPR – will force a shift in the market. 

It’s time to end the perception that sticking some plant compounds in beauty products is enough to make them ‘green’. CRISPR makes it possible to genuinely address the challenge of sustainability across the global beauty industry and finally turn our cosmetics truly green.

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