In precision oncology, tissue quality plays a pivotal role in maintaining data integrity. We explore the impact of standardizing tissue collection and processing on data quality, and how this helps enhance patient outcomes as well as our understanding of cancer. Insights from tissue samples play an important role across the drug life cycle – from […]
The life sciences ecosystem is facing a critical moment of transformation, driven by a new generation of startups that adopt a novel approach to scaling up. Unwilling to conform to the status quo, these life sciences startups are challenging conventional methods by adopting a tiger team approach—a dynamic and agile strategy to tackle the intricate […]
In the rapidly evolving healthcare landscape, cell and gene therapies (CGTs) have emerged as revolutionary treatments offering hope to patients with previously incurable diseases. However, the success of CGTs hinges on maintaining integrity through the supply chain, a task made daunting by the extreme temperature sensitivity of these therapies. We delve into the critical role […]
In most cases, chronic inflammation is known to lead to cancer, however, the mechanisms behind this are not fully understood. Preclinical models in immuno-oncology are the first step towards a better understanding of cancer mechanisms, improved treatments and prevention of cancer caused by inflammation. Inflammation is the immune system’s natural response to bacterial, viral, and […]
Thanks to their unique features, bispecific antibodies are the fastest-evolving class of biotherapeutics. However, the enormous clinical potential of their unconventional design is accompanied by equally large challenges. How can we ensure reliable production and quality control of therapeutic bispecific antibodies? Compared to monoclonal antibodies, bispecific antibodies (bsAbs) have two different binding areas that recognize […]
Drug screening follows the funnel principle – the higher the number and diversity of compounds assayed, the better the chances to identify meaningful hits that turn into promising clinical candidates. Robust high throughput screening assays to monitor target activity are key to reaching this goal in a reasonable time. With low-hanging fruits already ticked off […]
Since the implementation of the EU General Data Protection Regulation (‘GDPR’) on May 25, 2018, many countries have enacted similar laws to allow for the unhindered flow of personal data. This has caused a ripple effect of GDPR-like laws worldwide, with unique versions making international business more difficult than ever before. This difficulty is particularly […]
“Are these cells potent enough?” is a major question in cell therapy. It’s a challenging question to answer with the traditional methods for cell function analysis. The issue lies in the heterogeneity of cell populations. A single-cell view of immune cell activities, such as cytokine or antibody secretion, is critical to determine the potency of […]