News and Trends 5 Jan 2023 Researchers discover new type of CRISPR gene scissors …to its guide RNA. Targeting RNA triggers collateral nucleic acid cleavage that degrades RNA, single-stranded DNA, and double-stranded DNA. This activity leads to cell arrest, presumably by damaging DNA and… January 5, 2023 - 4 minutesmins - By Jim Cornall Share WhatsApp Twitter Linkedin Email
Best in Biotech 30 Jan 2025 Seven genome sequencing companies to look out for …DNA template to create long single-stranded DNA molecules to avoid errors such as index hopping – when sequencing reads are incorrectly assigned to the wrong sample in a pool. Its… January 30, 2025 - 9 minutesmins - By Roohi Mariam Peter Share WhatsApp Twitter Linkedin Email
News and Trends 25 May 2022 Duke Street Bio enters stage with next-generation cancer therapies …chairman and co-founder of Duke Street Bio, told us. Other companies researching cancer therapies based on DNA repair include Artios, which is developing DNA damage response inhibitors and raised €129M… May 25, 2022 - 3 minutesmins - By Susannah Rodgers Share WhatsApp Twitter Linkedin Email
News and Trends 17 Oct 2022 PerkinElmer’s Horizon Discovery: the lowdown on base editing …the human genome. However, the creation of double stranded DNA breaks (dsDNA), while central to the function of the “bacterial immune system” from which CRISPR was derived, is not ideal… October 17, 2022 - 5 minutesmins - By Jim Cornall Share WhatsApp Twitter Linkedin Email
News and Trends 1 Aug 2022 BioMed X Institute and Merck start new oncology research project …main objective of this research group is to develop an atlas of extrachromosomal DNA (ecDNA) in human cancer tissues and trace back the mechanisms of ecDNA formation and function. Extrachromosomal… August 1, 2022 - 3 minutesmins - By Jim Cornall Share WhatsApp Twitter Linkedin Email
News and Trends 19 Jun 2019 EU Gives Lynparza Green Light as First-Line Ovarian Cancer Treatment …disrupting DNA damage repair in cancer. Martin’s company Artios Pharma is developing drugs targeting a different DNA damage repair protein. The French biotech Onxeo is developing DNA drugs preventing the… June 19, 2019 - 3 minutesmins - By Jonathan Smith Share WhatsApp Twitter Linkedin Email
Best in Biotech 6 Oct 2022 15 biotech companies shaking up the scene in Cambridge …2016 Artios Pharma is developing drugs that inhibit an enzyme called DNA polymerase theta, which plays a role in multiple DNA repair processes. The levels of this enzyme are typically… October 6, 2022 - 9 minutesmins - By Helen Albert Share WhatsApp Twitter Linkedin Email
In Depth 6 Feb 2018 CRISPR/Cas9: Could the Gene Editing Technology be the Future of Drug Discovery? …a double-strand break in the DNA, which is repaired by the cell’s error-prone DNA repair machinery. That alone is usually knocks-out the gene of interest and allows scientists to study… February 6, 2018 - 9 minutesmins - By Melanie De Almeida Share WhatsApp Twitter Linkedin Email
Startup Scout 26 Aug 2022 Epic Bio makes gene therapies by editing the epigenome …control which genes become proteins. Epic Bio’s therapies involve fusing together a protein that binds to DNA with a so-called modulator protein that can make epigenetic changes to the DNA… August 26, 2022 - 4 minutesmins - By Jonathan Smith Share WhatsApp Twitter Linkedin Email
News and Trends 28 Nov 2022 Localizing BRCA gene mutations to better treat ovarian cancer …the DNA-binding domain, the drug is actually much more effective.” DNA-binding domains are protein motifs that are capable of binding to the DNA, and are involved in the regulation of… November 28, 2022 - 5 minutesmins - By Jim Cornall Share WhatsApp Twitter Linkedin Email
Podcast 5 Apr 2024 Colossal Biosciences’ 2028 goal: Bringing back the woolly mammoth …at the ancient DNA assembly that was needed. They also looked to improve the pipelines for ancient DNA, which is a different process to non-ancient and massively degraded DNA. Harnessing… April 5, 2024 - 8 minutesmins - By Jim Cornall Share WhatsApp Twitter Linkedin Email
News and Trends 25 Feb 2021 Legal Fights Accompany Big Fundraises in Liquid Biopsy Scene …identify solid tumors from tiny amounts of cancer DNA in a blood sample, which is known as circulating tumor (ct)DNA. This technology could provide an easier diagnostic alternative to invasive… February 25, 2021 - 5 minutesmins - By Anita Chakraverty Share WhatsApp Twitter Linkedin Email