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VarmX, a biotech company focusing on the development of innovative approaches for the reversal of anticoagulation, has successfully raised an additional €30 million ($32.2 million) in a Series B2 financing round. The round was led by Sound Bioventures while the European Innovation Council (EIC) Fund also joined as a new investor. Existing investors EQT Life Sciences (formerly LSP), Inkef, Lundbeckfonden BioCapital, Ysios Capital, BioGeneration Ventures (BGV), InnovationQuarter (IQ) and Libertatis Ergo Holding (LEH) all participated in the Series B2 round. The proceeds from the financing will enable VarmX to obtain investigational new drug (IND) approval for its lead compound VMX-C001 and to complete preparations for the pivotal clinical trial, including large-scale manufacturing. VarmX has completed enrollment of VMX-C001’s first-in-human study, to demonstrate safety and provide clinical proof of concept of the compound. The company will present initial data at the International Society on Thrombosis and Haemostasis conference in Montreal in June. Full study results will be available later this year. VarmX looking to reduce risks VMX-C001 is a modified recombinant human blood clotting factor X that enables blood to clot normally in the presence of factor Xa blood clotting inhibitors. It is being developed with the aim to facilitate the fast, safe and effective treatment of severe spontaneous bleeds in patients that are taking direct oral anticoagulant blood thinners (DOACs) and, in addition, to enable patients on this class of blood thinners to undergo emergency surgery without the risk of bleeding associated with FXa DOACs. The compound has the potential for a strong and differentiated profile, including universal and single dose reversal, ease-of-use and safety that supports emergency care use, and it shows promise for applications in other indications. Jan Öhrström, CEO of VarmX, said: “We are delighted to welcome Sound Bioventures and the EIC Fund to our strong syndicate of leading life sciences investors as we move to the next stage of VarmX’s growth path. Factor Xa-DOAC induced bleeding is becoming an increasingly frequent problem as the use of these anticoagulants increases, including due to the future availability of generics, and more users are experiencing bleeding problems. However, the opportunities for effective, safe treatments to prevent spontaneous bleeding, especially during surgery, remain limited. This funding will enable us to move the development of our VMX-C001 program further forward and bring it closer to helping patients.” Casper Breum, managing partner at Sound Bioventures, said: “We believe that VMX-C001 could be a differentiated new option for hundreds of thousands of patients worldwide, which is why we were keen to be part of this Series B2 round. There is limited availability of Factor Xa DOAC reversal agents and we believe VMX-C001 could make a significant difference.” Hermann Hauser, the EIC Fund Board member, added: “The EIC Fund aims at backing European innovators in scaling their journey and VarmX is a great example of how the European Union is helping top innovators. The EIC Fund's ambitious commitment, alongside other investors, is an important step to boost their development and bring their innovation closer to patients.”

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