Aldevron launches type-V CRISPR Nuclease

January 20, 2023 - 2 minutes
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Aldevron, which develops and manufactures plasmid DNA, RNA and proteins for the biotech industry, has launched Eureca-V Nuclease, the wild-type MAD7 CRISPR Type-V nuclease, licensed from Inscripta, at Research Grade, with GMP to follow.   

Aldevron’s launch at Advanced Therapies Week of Eureca-V Nuclease expands the toolkit of available CRISPR nucleases for therapeutic, diagnostic, and agricultural workflows. Purchase of Eureca-V Nuclease conveys a pass-through license for research use, enabling clients to thoroughly evaluate the product without committing to a long-term licensing agreement.   

“The availability of Eureca-V drives forward the entire genomics medicine industry and enhances Aldevron’s position as a supplier of choice for CRISPR drug substances and drug products,” said Tom Foti, vice president/general manager of Aldevron’s protein business unit.

“We are proud to work alongside our partners at Inscripta to bring the innovative, off-the-shelf catalog product to market now as well as provide a clear path to GMP in 2023.”  

Eureca-V at Research Grade ensures that translational CRISPR research can continue at an accelerated pace. The product will support academic and commercial research scientists seeking a wild-type, Type-V CRISPR nuclease that targets T-rich regions of the genome.  

Aldevron addressing global health issues

“We are thrilled to offer Eureca-V product at research grade starting today, and later this year, our clients can expect a smooth transition to our GMP product,” said Venkata Indurthi, chief scientific officer at Aldevron. 

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“Aldevron’s extensive history in CRISPR nucleases allows researchers to develop therapies that will eventually address global health issues.”   

Eureca-V will be Aldevron’s third GMP CRISPR nuclease and the first Type-V nuclease available as a GMP catalog product. Aldevron is a leader in the supply of critical raw materials and reagents for cell and gene therapy manufacturing; the company’s portfolio of CRISPR nucleases are applied worldwide in preclinical and clinical research applications.   

The initial license agreement with Inscripta was announced in May 2022.  

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