Could your nose lead to major discoveries in antibiotic production? Genome mining of nose bacteria has revealed a new powerful antibiotic.
Functional genomics offers a powerful tool for the isolation and detection of novel antibiotics, as the data obtained from it can be used to describe gene functions and interactions. The human microbiome has been largely studied to assess antimicrobial compounds that could potentially be used to defeat different harmful species, but expressing of all the resistance genes is not a simple task. At last, a research group from Tübingen, Germany, is making it work!
The University of Tübingen, Germany, which recently participated to the 2016 EuroScience Open Forum in Manchester, UK, works on Staphylococcus lugdunensis. (This bacteria’s name comes from Lugdunum, the Latin name for Lyon, France, where the organism was first isolated!). This bacteria is Gram-positive with spherical cells able to produce lugdunin, which it can use to defeat powerful skin infections caused by S. aureus in mice.
The team examined a library of S.