Will the Leading Italian Biotech soon have its First Cell therapy on the Market?

28/06/2016 - 2 minutes

MolMed has received conditional market approval for Zalmoxis, an ex vivo genetically engineered cell therapy that stops immune rejection of transplanted hematopoietic stem cells. This is a big step forward in a key treatment for blood cancers.

molmed_gene_cell_therapy_blood_cancerA transplant of hematopoietic stem cells (cells that give origin to blood cells) is often used as part of treatments for blood cancers. However, it’s not always easy to find a fully compatible donor. Because of this, high-risk patients often have to undergo haploidentical transplants with a partial match (usually the stem cells of a sibling or a parent).

Partial match transplants carry the risk of graft versus host disease (GvHD), a life-threatening immune reaction caused by the genetic disparity between patient and donor.

MolMed’s Zalmoxis is tackling this issue by genetically engineering donor immune system T-cells to carry an inducible ‘suicide gene‘. This gene can be used as a switch to control GvHD (something also engineered for CAR-T),

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