Immune memory research could lead to next generation of epigenetic drugs

Dr. Grégoire Stik, group leader at the Josep Carreras Leukaemia Research Institute and co-author of the study.
Dr. Grégoire Stik, group leader at the Josep Carreras Leukaemia Research Institute and co-author of the study.

A team of researchers has discovered that the memory of the immune system relies on characteristic epigenetic features and a specific 3D arrangement of the DNA in the nucleus of memory cells, allowing for a fast activation of these cells. 

These features are altered in chronic inflammation diseases like asthma and could be important in autoimmune diseases and cancer.

The research team consists of scientists from the Erasmus University Medical Center in the Netherlands, and the Centre for Genomic Regulation (CRG) and the Josep Carreras Leukaemia Research Institute, both in Spain.

The immune system is one of the most complex parts of our body. It keeps us healthy by getting rid of parasites, viruses or bacteria, and by destroying damaged or cancer cells. One of its most intriguing abilities is its memory: upon first contact with a foreign component (antigens) our adaptive immune system takes around two weeks to respond, but responses afterwards are much faster, as if the cells “remembered” the antigen. 

But how is this memory attained? 

In a recent publication, the team of researchers, coordinated by Ralph Stadhouders, from Erasmus MC, and Gregoire Stik, group leader at the Josep Carreras Leukaemia Research Institute, provides new clues on immune memory.

Comparing immune cell response

In their research paper, published in the journal Science Immunology, the first-author Anne Onrust-van Schoonhoven and colleagues compared the response of immune cells that had never been in contact with an antigen (called naïve cells) with cells previously exposed to antigen (memory cells). They focused on the differences in the epigenetic control of the cellular machinery and the nuclear architecture of the cells, two mechanisms that could explain the quick activation pattern of memory cells.

While all the cells in an individual have the same genetic information, different cell types access to different parts of the DNA. The term “epigenetics” encompasses the mechanisms that dynamically control this access. The results of the research team revealed a particular epigenetic signature in memory cells, resulting in the rapid activation of a crucial set of genes compared to naive cells. 

These genes were much more accessible to the cellular machinery, in particular to a family of transcription factors called AP-1. 

However, this epigenetic signature was just the tip of the iceberg. It is known that the position of the DNA in the nucleus is not random and reflects the cell’s activation state. The researchers found that the 3D distribution of DNA in the nucleus is different between naïve and memory immune cells. Key genes for the early immune response are grouped together and under the influence of the same regulatory regions, called enhancers. 

Although most of the research has focused on healthy cells, the scientific team wondered whether any of the mechanisms found could, when altered, explain actual diseases in which the immune system plays an important role. To address this question, they analyzed immune cells from chronic asthma patients and found that the circuits identified as key for an early and strong immune response were overactivated.

The epigenetic control of the immune system is a blossoming field and discoveries like the ones by Stik and colleagues are setting the stage for the next generation of epigenetic drugs and treatments, targeting autoimmune diseases and cancer.

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