Green light for Ascendis’ Phase III in Growth Hormone Deficiency

02/08/2015 - 2 minutes

It seems like the €48M Series D financing and the public introduction on the NASDAQ have paid off. Danish Ascendis Pharma announced positive top-line results from a Phase II study that evaluated the once-weekly TransCon Growth Hormone in children with growth hormone deficiency.

After Zosano, Ascendis was the second European company that went public at the NASDAQ this year. The raised $111.5M (€102M) mainly paid the development of the company’s in-house growth hormone treatment. Today, this project is one step closer to the market.

Great Phase II results get the all-clear for the next level. The six month Phase 2 study was conducted in 53 treatment-naïve, pre-pubertal children with growth hormone deficiency. Three doses of Ascendis’ TransCon Growth Hormone were compared to Pfizer’s approved treatment Genotropin. The latter is one out of two approved long-acting growth hormone products on the market. Both use unmodified growth hormone as the active agent.

Ascendis uses its TransCon technology to create enhanced prodrug versions of already existing drugs.

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