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car t cells regulations

News and Trends 20 Dec 2017

How to Deal with Regulations to Get Approval for CAR-T Cells

…reasonably assimilated into guidelines is finally emerging. Challenges ahead There are still many challenges that need to be properly addressed when developing CAR-T cells. These include viral vector testing, establishing…

December 20, 2017 - 8 minutesmins - By Timothé Cynober

gene therapy

News and Trends 14 Dec 2022

Replay targets genetic brain disorders with new gene therapy company, Kaleibe

…since the company’s formation in July and will leverage Replay’s high payload capacity herpes simplex virus (HSV) delivery vector, synHSV, to target genetic brain disorders. Kaleibe’s co-founders include Richard Wade-Martins,…

December 14, 2022 - 4 minutesmins - By Jim Cornall

Billion euro European biotech

Best in Biotech 20 Dec 2021

The Billion-Euro European Biotech Companies in 2022

…of its inactivated Covid-19 vaccine. The company’s vaccine candidate is made up of a ‘killed’ version of SARS-CoV-2, the virus causing Covid-19. The trial compared it with AstraZeneca’s adenoviral vector-based…

December 20, 2021 - 12 minutesmins - By Larissa Warneck-Silvestrin

lungs cystic fibrosis

News and Trends 20 Jun 2023

Anoat raises funds to tackle cystic fibrosis

…$38 million of financing, including support from the Cystic Fibrosis Foundation. Massachusetts-based Carbon is harnessing novel parvovirus vectors that can deliver larger gene therapy payloads with enhanced tissue specificity and…

June 20, 2023 - 3 minutesmins - By Jim Cornall

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tcr-t therapy

In Depth 3 Sep 2024

Adaptimmune: The long road toward finally bringing the first TCR-T cell therapy to the market

…for metastatic or unresectable synovial sarcoma in more than a decade, and the first TCR-T therapy to enter the market. “It’s the first product where we use a lentiviral vector…

September 3, 2024 - 7 minutesmins - By Willow Shah-Neville

CRISPR AI

In Depth 18 Dec 2024

AI + CRISPR: The explosive fusion that will redefine biotechnology

…These CRISPR tools overcome delivery challenges, particularly for therapies requiring delivery via viral vectors or lipid nanoparticles, making in vivo gene-editing therapies feasible and safer. In April 2024, Mammoth Biosciences…

December 18, 2024 - 6 minutesmins - By Jules Adam

stem cells skin butterfly boy2 1

News and Trends 9 Nov 2017

Doctors Use Genetically Modified Stem Cells to Give a Boy New Skin

…poor prognosis forced doctors to act, engineering Hassan’s stem cells to include an intact copy of the missing Lamb3 gene with retroviral vectors. The modified cells were then cultivated in…

November 9, 2017 - 3 minutesmins - By Alex Dale

Gates Foundation Oxitec Malaria Genetically Modified Mosquitoes

News and Trends 20 Jun 2018

Gates Foundation and Oxitec Fight Malaria with Genetically-Modified Mosquitoes

…of the most important vectors of malaria in America. “Genetically-modified mosquitoes are showing promise in controlling other vector-borne diseases, so we look forward to exploring their use alongside complementary interventions…

June 20, 2018 - 2 minutesmins - By Clara Rodríguez Fernández

gmo gene editing europe2 1

In Depth 31 Jan 2018

Why Does Europe Lag Behind the US and China in the Gene Editing Race?

…will continue, meaning off-target effects will be limited. Moreover, previous trials using viral vectors have shown that off-target mutagenesis is unlikely to have ill effects. While ex vivo gene editing…

January 31, 2018 - 6 minutesmins - By Ekaterina Perets

valneva covid 19 vaccine

News and Trends 16 May 2022

Valneva’s Covid-19 Vaccine Contract in Dire Straits as EU Approval Lags

…candidate evoked an immune response against Covid-19 that was comparable to the effect of AstraZeneca’s viral vector vaccine in a phase III trial in 2021, with fewer side effects. Valneva…

May 16, 2022 - 3 minutesmins - By Jonathan Smith

dendritic cell cancer immunotherapy

News and Trends 10 Dec 2018

Scientists Repurpose Skin Cells to Fight Cancer

…told me that there are lots of regulatory hurdles for cancer immunotherapy, especially those involving viral vectors to express genes. “The publication from Lund is a very high-tech study, but…

December 10, 2018 - 3 minutesmins - By Jonathan Smith

Cancer immunotherapy

Best in Biotech 9 May 2023

5 cancers that immunotherapy can cure

…of the bladder. However, for non-muscle invasive cancers that do not respond to treatment with BCG, the FDA recently approved the first ever adenoviral vector-based gene therapy called Nadofaragene firadenovec…

May 9, 2023 - 7 minutesmins - By Willow Shah-Neville