Inflammatory disease Archives

In Depth 12 Oct 2023

Can immunometabolism-based therapies transform the way cancers and autoimmune diseases are treated?

The immune system protects our bodies from foreign invaders, but sometimes, when it malfunctions, it can result in life-threatening autoimmune disorders. But what if the immune system could be regulated to counter these diseases? Immunometabolism, an emerging field in therapeutics, aims to rein in autoimmunity altogether. According to Neil Weir, chief executive officer (CEO) of […]

October 12, 2023 - 9 minutesmins - By Roohi Mariam Peter

In Depth 15 Aug 2023

Can stem cell treatment repair damaged knees?

Scientists’ fascination with amphibians like axolotls and newts, animals that are capable of scarlessly regrowing their limbs, sparked the idea of possibly replicating this in humans. Since 1958, when French oncologist Georges Mathe performed the first-ever stem cell transplantation – to save six nuclear researchers who were accidentally exposed to radiation – the technology has […]

August 15, 2023 - 7 minutesmins - By Roohi Mariam Peter

News and Trends 31 Jul 2023

Biogen acquiring Reata Pharmaceuticals for $7.3B

Biogen Inc. and Reata Pharmaceuticals, Inc. have entered into a definitive agreement under which Biogen has agreed to acquire Reata for $172.50 per share in cash, reflecting an enterprise value of approximately $7.3 billion. Reata has made advancements developing therapeutics that regulate cellular metabolism and inflammation in serious neurologic diseases. Reata’s FDA-approved SKYCLARYS (omaveloxolone) is […]

July 31, 2023 - 3 minutesmins - By Jim Cornall

Podcast 20 Jul 2023

Beyond Biotech podcast 55: Inflammasomes

This week on our podcast, we’re talking about inflammasome inhibitors with Alan Watt, CEO of NodThera. The company recently announced it is the first to show a reduction in neuroinflammation with an inflammasome inhibitor. NodThera announced positive initial data from four subjects in the elderly volunteer stage of its phase Ib/IIa study evaluating the effects […]

July 20, 2023

Dr. Grégoire Stik, group leader at the Josep Carreras Leukaemia Research Institute and co-author of the study.

News and Trends 11 Jul 2023

Immune memory research could lead to next generation of epigenetic drugs

A team of researchers has discovered that the memory of the immune system relies on characteristic epigenetic features and a specific 3D arrangement of the DNA in the nucleus of memory cells, allowing for a fast activation of these cells. These features are altered in chronic inflammation diseases like asthma and could be important in […]

July 11, 2023 - 3 minutesmins - By Jim Cornall

News and Trends 11 Jul 2023

NodThera first to show reduction in neuroinflammation with inflammasome inhibitor

NodThera has announced positive, initial data from four subjects in the elderly volunteer stage of its phase Ib/IIa study evaluating the effects of its lead candidate NT-0796 on inflammatory and disease-specific biomarkers in the blood and cerebrospinal fluid (CSF). NodThera is a clinical-stage biotech developing brain-penetrant NLRP3 inflammasome inhibitors to treat chronic inflammatory diseases. Alan […]

July 11, 2023 - 3 minutesmins - By Jim Cornall

News and Trends 20 Jun 2023

NodThera announces positive inflammatory disease data

NodThera has announced positive data from first-in-human studies of its lead therapeutic candidates, NT-0249 and NT-0796. In the studies, both candidates were shown to clearly inhibit the NLRP3 inflammasome, a highly validated drug target that plays a pivotal role in controlling inflammatory diseases. The differentiated design characteristics of each candidate enabled them to penetrate different […]

June 20, 2023 - 3 minutesmins - By Jim Cornall

Best in Biotech 22 May 2023

Five recent advancements in arthritis research over the past year

Today, more than 350 million people across the world – and nearly a quarter of American adults – have arthritis. A condition characterized by pain, inflammation and stiffness in the joints – often owing to a hyperactive immune system causing the body to attack its own joint tissues, in the case of rheumatoid arthritis – […]

May 22, 2023 - 8 minutesmins - By Roohi Mariam Peter

News and Trends 17 May 2023

Diagnosing inflammatory diseases with synthetic peptides

Common inflammatory disorders such as ulcerative colitis and Crohn’s disease can be diagnosed or monitored by measuring the protein calprotectin in stool samples, while serum levels of calprotectin could be used to monitor the inflammation status in rheumatoid arthritis. Calprotectin concentrations in patient samples are typically determined using antibodies that bind and detect the protein, […]

May 17, 2023 - 3 minutesmins - By Jim Cornall

News and Trends 9 May 2023

Gilead boosts oncology pipeline with XinThera acquisition

Gilead Sciences, Inc. has announced the acquisition of all outstanding shares of XinThera, a privately held biotech company in San Diego. Gilead Sciences said the acquisition complements its existing clinical development priorities by adding additional pipeline assets for well-validated targets in oncology and inflammation. Through the acquisition, Gilead Sciences gains the rights to a portfolio […]

May 9, 2023 - 3 minutesmins - By Jim Cornall

News and Trends 27 Apr 2023

Patients with asthma and other inflammatory lung diseases can be treated ‘in a fundamentally new way’

Arrowhead Pharmaceuticals Inc. has announced interim results from an ongoing phase 1/2 clinical study of ARO-RAGE, an investigational RNA interference (RNAi) therapeutic designed to reduce production of the receptor for advanced glycation end products (RAGE) as a potential treatment for inflammatory pulmonary diseases, such as asthma. These data represent the first clinical demonstration of the […]

April 27, 2023 - 3 minutesmins - By Jim Cornall

Podcast 14 Apr 2023

Beyond Biotech podcast 41: Sarcoidosis

This week, to coincide with World Sarcoidosis Day, we talk about sarcoidosis with Marcin Szumowski, CEO and president of the management board of Molecure. World Sarcoidosis Day As part of Sarcoidosis Awareness Month, which is observed each April, World Sarcoidosis Day is held on April 13. But what is sarcoidosis? The Foundation for Sarcoidosis Research […]

April 14, 2023

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Inflammatory disease

Can immunometabolism-based therapies transform the way cancers and autoimmune diseases are treated?

Can stem cell treatment repair damaged knees?

Biogen acquiring Reata Pharmaceuticals for $7.3B

Beyond Biotech podcast 55: Inflammasomes

Immune memory research could lead to next generation of epigenetic drugs

NodThera first to show reduction in neuroinflammation with inflammasome inhibitor

NodThera announces positive inflammatory disease data

Five recent advancements in arthritis research over the past year

Diagnosing inflammatory diseases with synthetic peptides

Gilead boosts oncology pipeline with XinThera acquisition

Patients with asthma and other inflammatory lung diseases can be treated ‘in a fundamentally new way’

Beyond Biotech podcast 41: Sarcoidosis

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Illuminating biotech in the City of Light: Inside Paris’s thriving ecosystem

ASCO 2025: key highlights in cancer therapeutics

New report: Artificial intelligence and the future of antibody discovery

Stem cell therapy: a potential cure for hearing loss?

Connect with decision-makers and researchers worldwide for collaborative opportunities

Subscribe to our newsletter

Advertise with us

Illuminating biotech in the City of Light: Inside Paris’s thriving ecosystem

ASCO 2025: key highlights in cancer therapeutics

New report: Artificial intelligence and the future of antibody discovery

Stem cell therapy: a potential cure for hearing loss?

Connect with decision-makers and researchers worldwide for collaborative opportunities

Subscribe to our newsletter

Advertise with us

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